{"id":11647,"date":"2026-09-21T17:13:08","date_gmt":"2026-09-21T09:13:08","guid":{"rendered":"https:\/\/cn.dailyeconomic.com\/sh\/?p=11647"},"modified":"2026-09-21T17:13:08","modified_gmt":"2026-09-21T09:13:08","slug":"%e5%be%b7%e7%9d%bf%e6%99%ba%e8%8d%af%e5%8f%91%e5%b8%83%e7%94%9f%e5%91%bd%e7%a7%91%e5%ad%a6%e5%9f%ba%e5%ba%a7%e6%a8%a1%e5%9e%8b%e4%bd%93%e7%b3%bbintera-%ef%bc%8c%e9%a6%96%e4%b8%aa%e6%a8%a1%e5%9e%8b","status":"publish","type":"post","link":"https:\/\/cn.dailyeconomic.com\/sh\/2026\/09\/21\/11647.html","title":{"rendered":"\u5fb7\u777f\u667a\u836f\u53d1\u5e03\u751f\u547d\u79d1\u5b66\u57fa\u5ea7\u6a21\u578b\u4f53\u7cfbIntera \uff0c\u9996\u4e2a\u6a21\u578b\u805a\u7126\u86cb\u767d\u8d28\u4e0e\u5c0f\u5206\u5b50\u7ed3\u5408\u6784\u8c61\u9884\u6d4b"},"content":{"rendered":"

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Intera\u5b9a\u4f4d\u4e8e\u9762\u5411\u75be\u75c5\u7406\u89e3\u3001\u673a\u5236\u89e3\u6790\u3001\u836f\u7269\u8bbe\u8ba1\u4e0e\u60a3\u8005\u7814\u7a76\u7684\u751f\u547d\u79d1\u5b66\u57fa\u5ea7\u6a21\u578b\u4f53\u7cfb\u3002\u672c\u6b21\u53d1\u5e03\u7684InteraFold-Chem\u4e3b\u8981\u805a\u7126\u86cb\u767d\u8d28\u4e0e\u5c0f\u5206\u5b50\u7684\u7ed3\u5408\u6784\u8c61\u9884\u6d4b\uff0c\u5728\u836f\u7269\u7814\u53d1\u4e2d\uff0c\u8fd9\u7c7b\u7ed3\u6784\u4fe1\u606f\u53ef\u4e3a\u7814\u7a76\u4eba\u5458\u5206\u6790\u5206\u5b50\u4f5c\u7528\u65b9\u5f0f\u3001\u63d0\u51fa\u5206\u5b50\u6539\u9020\u65b9\u6848\u63d0\u4f9b\u53c2\u8003\u3002<\/p>\n

\u5728\u516c\u53f8\u62ab\u9732\u7684\u6280\u672f\u62a5\u544a\u6240\u8ff0\u7684\u8bc4\u6d4b\u4e2d\uff0cInteraFold-Chem\u7684\u7ed3\u5408\u6784\u8c61\u9884\u6d4b\u6210\u529f\u7387\u4e3a54.4%\uff0c\u9ad8\u4e8e\u672c\u6b21\u7eb3\u5165\u7684Protenix-v2\u3001Chai-1\u548cBoltz-2\u5bf9\u7167\u6a21\u578b[1]\u3002<\/p>\n

1.\u8bc4\u6d4b\u4e2d\u53d6\u5f97\u4e09\u9879\u6838\u5fc3\u6307\u6807\u6700\u4f18\u7ed3\u679c\uff0c\u8d85\u8d8a\u884c\u4e1a\u5934\u90e8\u6a21\u578b<\/strong><\/p>\n

\u5728\u6280\u672f\u62a5\u544a\u6240\u8ff0\u7b5b\u9009\u89c4\u5219\u4e0b\u5f62\u6210\u7684445\u4e2a\u6d4b\u8bd5\u6837\u672c\u4e0a\uff0cInteraFold-Chem\u7684\u7ed3\u5408\u6784\u8c61\u9884\u6d4b\u6210\u529f\u7387\u4e3a54.4%\uff0c\u8f83\u672c\u6b21\u5bf9\u7167\u6a21\u578b\u4e2d\u6210\u529f\u7387\u6700\u9ad8\u7684Protenix-v2\uff0848.5%\uff09\u63d0\u9ad85.9%\u3002\u8be5\u6307\u6807\u6309\u914d\u4f53RMSD\u76842 \u00c5\u9608\u503c\u7edf\u8ba1\u9884\u6d4b\u6784\u8c61\u63a5\u8fd1\u5b9e\u9a8c\u53c2\u8003\u7ed3\u6784\u7684\u6837\u672c\u6bd4\u4f8b\u3002<\/p>\n

InteraFold-Chem\u7684\u914d\u4f53RMSD\uff08\u5747\u65b9\u6839\u504f\u5dee\uff09\u4e2d\u4f4d\u6570\u4e3a1.426\u00c5\uff0c\u590d\u5408\u7269lDDT\uff08\u5c40\u90e8\u8ddd\u79bb\u5dee\u5f02\u6d4b\u8bd5\uff09\u8bc4\u5206\u4e3a0.924\uff0c\u5206\u522b\u53cd\u6620\u914d\u4f53\u9884\u6d4b\u504f\u5dee\u4e0e\u590d\u5408\u7269\u5c40\u90e8\u7ed3\u6784\u4e00\u81f4\u6027\u3002\u5728\u672c\u6b21\u8bc4\u6d4b\u8bbe\u7f6e\u548c\u53c2\u8bc4\u6a21\u578b\u8303\u56f4\u5185\uff0cInteraFold-Chem\u53d6\u5f97\u4e0a\u8ff0\u4e09\u9879\u6307\u6807\u7684\u6700\u4f18\u7ed3\u679c\uff0c\u6bd4\u8f83\u7ed3\u8bba\u4ee5\u672c\u6b21\u8bc4\u6d4b\u8bbe\u7f6e\u548c\u53c2\u8bc4\u6a21\u578b\u8303\u56f4\u4e3a\u9650\u3002<\/p>\n

InteraFold-Chem\u4e0e\u53c2\u8bc4\u6a21\u578b\u7684\u4e09\u9879\u6307\u6807\u5bf9\u6bd4<\/strong><\/p>\n

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\u25b2\u56fe1\uff1aInteraFold-Chem\u3001InteraFold-Chem-RL\u3001Protenix-v2\u3001Chai-1\u4e0eBoltz-2\u7684\u8bc4\u6d4b\u7ed3\u679c<\/p>\n

2.\u8ba9\u7ed3\u6784\u6a21\u578b\u201c\u8bfb\u61c2\u5316\u5b66\u201d\uff0c\u7406\u89e3\u5c0f\u5206\u5b50\u4e0e\u9776\u70b9\u7684\u7ed3\u5408\u65b9\u5f0f<\/strong><\/p>\n

\u5019\u9009\u5206\u5b50\u4ee5\u4ec0\u4e48\u59ff\u6001\u4e0e\u9776\u70b9\u7ed3\u5408\uff0c\u662f\u836f\u7269\u8bbe\u8ba1\u4e2d\u7684\u5173\u952e\u95ee\u9898\u3002InteraFold-Chem\u5c06\u539f\u5b50\u7ea7\u5316\u5b66\u4fe1\u606f\u878d\u5165\u5168\u539f\u5b50\u7ed3\u6784\u9884\u6d4b\u6846\u67b6\uff0c\u56f4\u7ed5\u201c\u5c0f\u5206\u5b50\u53ef\u80fd\u5728\u9776\u70b9\u7684\u4ec0\u4e48\u4f4d\u7f6e\u3001\u4ee5\u4f55\u79cd\u65b9\u5f0f\u7ed3\u5408\u201d\u5f00\u5c55\u5efa\u6a21\uff0c\u4e3a\u5206\u6790\u6784\u6548\u5173\u7cfb\u4e0e\u63d0\u51fa\u5206\u5b50\u6539\u9020\u65b9\u6848\u63d0\u4f9b\u7ed3\u6784\u4f9d\u636e\u3002<\/p>\n

\u8fd9\u4e9b\u9884\u6d4b\u53ef\u7528\u4e8e\u5206\u6790\u5206\u5b50\u4e0e\u7ed3\u5408\u53e3\u888b\u7684\u7a7a\u95f4\u5173\u7cfb\uff0c\u5e2e\u52a9\u7814\u53d1\u4eba\u5458\u63d0\u51fa\u53ef\u4f9b\u5408\u6210\u4e0e\u5b9e\u9a8c\u68c0\u9a8c\u7684\u8bbe\u8ba1\u5047\u8bbe\u3002<\/p>\n

\u5728\u88c2\u89e3\u6027\u8f6c\u7cd6\u82f7\u9176\u4e0e\u6291\u5236\u5242\u590d\u5408\u7269\u7684\u56de\u987e\u6027\u6848\u4f8b\u4e2d\uff08PDB\u7f16\u53f7\uff1a8GFD\uff09\uff0cInteraFold-Chem\u9884\u6d4b\u7684\u914d\u4f53\u6784\u8c61\u4e0e\u5b9e\u9a8c\u53c2\u8003\u7ed3\u6784\u4e4b\u95f4\u7684RMSD\u4e3a1.10\u00c5\uff0c\u4f4e\u4e8e\u672c\u6b21\u91c7\u7528\u76842\u00c5\u6210\u529f\u5224\u5b9a\u9608\u503c\uff0c\u8f83\u597d\u5730\u8fd8\u539f\u4e86\u8be5\u6848\u4f8b\u4e2d\u914d\u4f53\u7684\u7ed3\u5408\u4f4d\u7f6e\u4e0e\u6784\u8c61\u3002<\/p>\n

8GFD\u590d\u5408\u7269\u5b9e\u9a8c\u7ed3\u6784\u4e0e\u5404\u6a21\u578b\u9884\u6d4b\u7ed3\u6784\u5bf9\u6bd4<\/strong><\/p>\n

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\u25b2\u56fe2\u4e0a\u6392\u4ece\u5de6\u81f3\u53f3\u4e3a8GFD\u590d\u5408\u7269\u6676\u4f53\u7ed3\u6784\u3001InteraFold-Chem\u53caInteraFold-Chem-RL\u9884\u6d4b\u7ed3\u6784\uff1b\u4e0b\u6392\u4e3aProtenix-v2\u3001Chai-1\u53caBoltz-2\u9884\u6d4b\u7ed3\u6784\u5404\u9762\u677f\u72ec\u7acb\u5c55\u793a\uff0c\u5b9a\u91cf\u6bd4\u8f83\u4ee5\u86cb\u767d\u8d28\u5bf9\u9f50\u540e\u7684\u914d\u4f53RMSD\u4e3a\u51c6\u3002\u672c\u56fe\u4e3a\u56de\u987e\u6027\u6848\u4f8b\u5c55\u793a[1]\u3002<\/p>\n

3.\u9762\u5411\u75be\u75c5\u5230\u60a3\u8005\u7684\u751f\u547d\u79d1\u5b66\u57fa\u5ea7\u6a21\u578b\u4f53\u7cfbIntera<\/strong><\/p>\n

\u6839\u636e\u516c\u53f8\u4ecb\u7ecd\uff0cIntera\u540d\u79f0\u53d6\u81ea\u201c\u667a\u80fd\u65f6\u4ee3\u201d\uff08Intelligence Era\uff09\uff0c\u4e5f\u547c\u5e94\u5bf9\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\uff08Interaction\uff09\u7684\u7814\u7a76\u3002\u8be5\u4f53\u7cfb\u4ee5\u75be\u75c5\uff08Disease\uff09\u3001\u673a\u5236\uff08Mechanism\uff09\u3001\u836f\u7269\uff08Medicine\uff09\u4e0e\u60a3\u8005\uff08Patient\uff09\u4e3a\u7814\u7a76\u6846\u67b6\uff0c\u8ba1\u5212\u901a\u8fc7\u7cfb\u5217\u6a21\u578b\u9010\u6b65\u62d3\u5c55\u76f8\u5173\u7814\u7a76\u80fd\u529b\u3002<\/p>\n

\u5176\u4e2d\uff0cInteraFold\u7528\u4e8e\u7814\u7a76\u9776\u70b9\u4e0e\u4e0d\u540c\u836f\u7269\u6a21\u6001\u7684\u7ed3\u5408\u6a21\u5f0f\uff0c\u672c\u6b21\u53d1\u5e03\u7684InteraFold-Chem\u805a\u7126\u5c0f\u5206\u5b50\u3002\u89c4\u5212\u4e2d\u7684InteraDesign\u9762\u5411\u5206\u5b50\u751f\u6210\u4e0e\u8bbe\u8ba1\uff0cInteraBio\u9762\u5411\u751f\u7269\u5b66\u7406\u89e3\u3002<\/p>\n

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\u6309\u7167\u516c\u53f8\u62ab\u9732\u7684\u53d1\u5e03\u8ba1\u5212\uff0c\u5fb7\u777f\u667a\u836f\u5c06\u4e8e2026\u5e74\u7b2c\u56db\u5b63\u5ea6\u63a8\u51faInteraFold-Chem\u5728\u7ebf\u670d\u52a1\uff0c\u652f\u6301\u86cb\u767d\u8d28\u4e0e\u5c0f\u5206\u5b50\u7ed3\u5408\u6784\u8c61\u9884\u6d4b\u7814\u7a76\uff0c\u5e76\u9646\u7eed\u63a8\u51fa\u6297\u4f53\u2013\u6297\u539f\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u6a21\u578bInteraFold-Ab\u53ca\u591a\u80bd\u2013\u86cb\u767d\u8d28\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\u6a21\u578bInteraFold-Peptide\u7b49\u6a21\u578b\u3002<\/p>\n

4.\u4ee5\u771f\u5b9e\u836f\u7269\u7814\u53d1\u79ef\u7d2f\u652f\u6491\u57fa\u5ea7\u6a21\u578b\u8fed\u4ee3<\/strong><\/p>\n

\u9664\u6a21\u578b\u7814\u53d1\u5916\uff0c\u5fb7\u777f\u667a\u836f\u6b63\u5728\u63a8\u8fdb\u5341\u6570\u6761\u81ea\u6709\u836f\u7269\u7ba1\u7ebf\u7684\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u5c06\u5206\u5b50\u53d1\u73b0\u3001\u5b9e\u9a8c\u7814\u7a76\u548c\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u5e94\u7528\u573a\u666f\u4e0e\u6570\u636e\u53cd\u9988\u7528\u4e8e\u57fa\u5ea7\u6a21\u578b\u7814\u7a76\u3002<\/p>\n

\u8fc7\u53bb5\u5e74\uff0c\u5fb7\u777f\u667a\u836f\u4f9d\u6258\u65e2\u6709AI\u5e73\u53f0\u4e0e\u7814\u53d1\u4f53\u7cfb\uff0c\u56f4\u7ed5GPCR\u7b49\u9776\u70b9\uff0c\u4ee5\u53ca\u5206\u5b50\u80f6\u3001\u522b\u6784\u8c03\u63a7\u548c\u53cc\u9776\u70b9\u7b49\u96be\u6210\u836f\u836f\u7269\u7814\u53d1\u65b9\u5411\u5f00\u5c55\u7814\u7a76\uff0c\u53d6\u5f97\u4e867\u4e2a\u4e34\u5e8a\u524d\u5019\u9009\u5316\u5408\u7269\uff08PCC\uff09\u30012\u6761\u4e34\u5e8a\u7ba1\u7ebf\u7b49\u9636\u6bb5\u6027\u6210\u679c\u3002\u5176\u4e2d\uff0c\u81ea\u7814GLP-1RA\u53e3\u670d\u5c0f\u5206\u5b50MDR-001\u4ece\u7acb\u9879\u5230\u542f\u52a8\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7528\u65f6\u7ea64.5\u5e74\u3002<\/p>\n

AI\u5236\u836f\u5e73\u53f0\u7684\u4ef7\u503c\u4e0d\u4ec5\u53d6\u51b3\u4e8e\u6a21\u578b\u8868\u73b0\uff0c\u4e5f\u53d6\u51b3\u4e8e\u7814\u53d1\u53cd\u9988\u7684\u6df1\u5ea6\u3002\u4ece\u4f53\u5916\u5b9e\u9a8c\u8d70\u5411\u4eba\u4f53\u4e34\u5e8a\uff0c\u771f\u5b9e\u7684\u836f\u4ee3\u3001\u5b89\u5168\u6027\u548c\u7597\u6548\u6570\u636e\u4e3a\u68c0\u9a8c\u6a21\u578b\u9884\u6d4b\u3001\u4f18\u5316\u540e\u7eed\u7814\u53d1\u63d0\u4f9b\u4e86\u66f4\u76f4\u63a5\u7684\u4f9d\u636e\u3002\u5fb7\u777f\u667a\u836f\u540e\u7eed\u5c06\u4f9d\u6258\u4e34\u5e8a\u7814\u53d1\u79ef\u7d2f\uff0c\u63a2\u7d22\u4e34\u5e8a\u6570\u636e\u5bf9\u75be\u75c5\u673a\u5236\u7814\u7a76\u4e0e\u836f\u7269\u8bbe\u8ba1\u7684\u53cd\u9988\u4f5c\u7528\uff0c\u9010\u6b65\u6784\u5efa\u4e34\u5e8a\u6570\u636e\u53cd\u9988\u95ed\u73af\uff08Clinical Data-in-the-Loop\uff09\uff0c\u63a8\u52a8Intera\u751f\u547d\u79d1\u5b66\u57fa\u5ea7\u6a21\u578b\u4f53\u7cfb\u4e0e\u771f\u5b9e\u836f\u7269\u7814\u53d1\u76f8\u4e92\u4fc3\u8fdb\u3002<\/p>\n

\u4ece\u7406\u89e3\u751f\u7269\u5b66\u3001\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u51fa\u53d1\uff0c\u5728\u771f\u5b9e\u836f\u7269\u7814\u53d1\u4e2d\u6301\u7eed\u9a8c\u8bc1\uff0c\u4ee5\u60a3\u8005\u83b7\u76ca\u4e3a\u76ee\u6807\uff0c\u662fIntera\u9762\u5411\u7684\u672a\u6765\u3002<\/p>\n

\u6280\u672f\u62a5\u544a\u4e0b\u8f7d\uff1a<\/strong>https:\/\/intera.mindrank.ai\/interafold-chem-report.pdf<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/strong><\/p>\n

[1] \u5fb7\u777f\u667a\u836f\u3002 InteraFold-Chem\u6280\u672f\u62a5\u544a\uff1aInteraFold-Chem: Integrating pretrained ligand representationsfor protein\u2013ligand pose prediction<\/p>\n

\u5173\u4e8e\u5fb7\u777f\u667a\u836f<\/strong><\/p>\n

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